Agrochemical Pesticide Fungicide Hymexazol CAS 10004-44-1

• CAS No.: 10004-44-1
• Formula: C4h5no2
• EINECS: 233-000-6
• Appearance: Liquid
• Application: Fungicide, Bactericide
• Usage Mode: Therapeutic Agent
• Model NO.: SV165
• Raw Material: Inorganic Fungicide
• Application Fields: Agricultural Fungicide
• Conductivity: Systemic Fungicide
• Composition: Organic
• Transport Package: 200L/Drum or as Customized
• Specification: 95%TC, 30%SL
• Trademark: SINOVID
• Origin: China
• HS Code: 3808919000
• Production Capacity: 10000L/Month

Product Description

Product Name:	Hymexazol
Synonyms:	TACHIGALOZE;TACHIGAREN;5-METHYLISOXAZOL-3-OL;5-Methyl-3(2H)-isoxazolone;AGRIZOL;3-hydroxy-5-methyl-isoxazol;5-Hydroxy-3-methylisoxazole;HYDROXYISOXAZOLE
CAS:	10004-44-1
MF:	C4H5NO2
MW:	99.09
EINECS:	233-000-6
Product Categories:	Agro-Products;FUNGICIDE;Oxazoles, Isoxazoles & Benzoxazoles;Heterocyclic Compounds;Heterocycles;Oxazoles, Isoxazoles & Benzoxazoles;Oxazole&Isoxazole
Mol File:	10004-44-1.mol

Hymexazol Chemical Properties

Melting point	80°C
Boiling point	185.54°C (rough estimate)
density	1.2992 (rough estimate)
vapor pressure	0.182 Pa (25 °C)
refractive index	1.4170 (estimate)
storage temp.	2-8°C
pka	5.91 (weak acid)
Water Solubility	65,100 mg l^-1 (20 °C)
form	Powder
Sensitive	Light Sensitive
Merck	14,4856
InChIKey	KGVPNLBXJKTABS-UHFFFAOYSA-N
CAS DataBase Reference	10004-44-1(CAS DataBase Reference)
EPA Substance Registry System	Hymexazol (10004-44-1)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-41-52/53
Safety Statements	26-39-61
WGK Germany	3
RTECS	NY2932000
HS Code	29349990
Toxicity	LD50 in male, female mice, rats (mg/kg): 2148, 1968, 4678, 3909 orally; 1297, 1167, 1924, 1884 s.c.; 445, 514, >1000, >1000 i.v.; in rats, rabbits (mg/kg): >10000, >2000 dermally (Nakamura, 1978)

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

Hymexazol Usage And Synthesis

Chemical Properties	White Solid
Uses	Pesticide.
Uses	Agricultural fungicide and plant growth regulator.
Uses	Hymexazol is used to control soil-borne diseases caused by Fusarium, Aphanomyces, Pythium, Corficium and Typhula spp. in rice, sugar beet, fodder beet, vegetables, cucurbits, ornamentals, carnations and forest tree seedlings. It is also used as a seed dressing and stimulates some plant growth.
Definition	ChEBI: A member of the class of isoxazoles carrying hydroxy and methyl substituents at positions 3 and 5 respectively. It is used worldwide as a systemic soil and seed fungicide for the control of diseases caused by Fusarium, Aphanomyces Pythium, and Corticium spp. in rice, sugarbeet, fodderbeet, vegetables, cucurbits, and ornamentals.
Synthesis Reference(s)	The Journal of Organic Chemistry, 48, p. 4307, 1983 DOI: 10.1021/jo00171a030
Metabolic pathway	Degradation of hymexazol in soil gave acetoacetamide and the product of rearrangement, 5-methyl-2(^3H)-oxazolone.H owever, in plants the fungicide was principally converted into its O- and N-glucoside conjugates in the roots and shoots. The two main metabolites of hymexazol found in the urine of rats were the O-glucuronide and sulfate conjugates.
Degradation	Hymexazol is stable under alkaline conditions and relatively stable in acidic conditions. It is stable to sunlight and heat (PM). It should be noted that the parent molecule is tautomeric. Hymexazol is highly volatile and will be lost by volatilisation unless it is covered or incorporated into soil. The fungicide was completely biodegraded in natural water at 30 °C in 2 weeks and at 10-13 °C in 2 months (Rebenok and Kolesnikova, 1983). Hymexazol is stable in sunlight but it is readily degraded by ultraviolet light. Photolysis of an aqueous solution of the fungicide at 253.7 nm, using a low pressure Hg lamp, afforded the oxazolinone (2) as the major product and at least two unidentified minor components. The oxazolinone (2) has been found in soil studies as described below and is a product of rearrangement formed via an aziridinone intermediate as shown in Scheme 1 (Nakagawa et al., 1974).